The analytical repertoire of BEVITAL is composed to answer specific questions addressed in epidemiological and clinical research based on large biobanks.

Complementary platforms are characterized by multiplexing and low volume consumption to save precious biobank material. Targeted metabolic profiling includes defined pathways, i.e. one-carbon metabolism, choline oxidation, transsulfuration, and tryptophan degradation pathway and co-factors involved. The repertoire also includes biomarkers of common confounders, such as smoking, inflammation and kidney function. This contrasts to untargeted metabolomics, which capture only abundant metabolites and with the inherent weakness of possible assay interference.
    Some news and unique products are summarized below:
  • Saving biobank material by combining platforms. A procedure involving combined sample workup for platforms B and H enabling quantification of 6 lipid-soluble and 26 water soluble biomarkers in 50 µL serum/plasma has been established. The method utilizes liquid-liquid extraction of the lipid soluble vitamins and further processing of the aqueous phase through the steps established for platform B.

  • C-Reactive protein, cystatin C and its variants in 20 µL
    of sample.
    A new method for the combined quantification of two important biomarkers of inflammation and renal function, C-reactive protein (CRP) and cystatin C, respectively, has been developed at BEVITAL. The method is characterized by low sample consumption, high capacity, and high precision, and has been designed for the assessment of biomarker status in precious samples from large biobanks.

  • Two review articles on vitamin B6 biomarkers. A review on vitamin B6 biomarkers has been published in Annual Review of Nutrition. It deals with both direct vitamin B6 biomarkers that measure B6 vitamers in plasma, serum and urine and functional biomarkers reflecting enzymatic or metabolic functions of vitamin B6, including novel markers like the PAr index and the HK/XA ratio. Another review on inflammation, vitamin B6 and related pathways has recently been published in Molecular Aspects of Medicine. Both articles are co-authored by scientists at BEVITAL.

  • Recovery of degraded biomarkers. The combined measurements of the degradation product and parent compound may correct for moderate biomarker decomposition. Such recovery assays have been validated and published for the conversion pyridoxal 5'-phosphate (PLP) to pyridoxal (PL), flavin mononucleotide (FMN) to riboflavin, for the oxidation of methionine to methionine sulfoxide and for the oxidation of 5-methyltetrahydrofolate to 4-alfa-hydroxy-5-methyltetrahydrofolate (hmTHF). In samples where folate has been extensively degraded beyond hmTHF, folate can be measured as p-aminobenzoylglutamate (pABG) equivalents by an assay involving oxidation and mild acid hydrolysis.

  • Analysis of metabolites and biomarkers in extract from cells or tissues. The methods used by Bevital have been developed and validated for analyses of metabolites in plasma, serum and/or urine. Occasionally, customers request analysis in cell or tissue extracts. In such cases, the method has to be validated and optimized for the actual extract and extraction procedure, to secure adequate performance of the method. Such validation and optimization include the following steps and considerations:
- Assessment of the approximate metabolite concentrations in representative extracts.

Initially, the customer must provide representative extracts. This will be used to determine the approximate concentration of metabolite. Such information is required for method validation (steps 2 to 3).

- Metabolite extraction including protein precipitation.

Preferably, the extraction should be carried out using the same procedure and precipitating agent as used for the method optimized for serum/plasma. Extraction could be carried out by the customer according to agreed procedure. Alternatively, extraction of frozen cell pellet or frozen tissue specimen could be carried out by Bevital. In both cases, the extraction solution (trichloric acid or perchloric acid) should be supplemented with deuterated internals standard for each metabolite, the concentration of which must be similar to the concentration of each metabolite, as obtained in step 1.

- Stability of metabolite.

The stability of the metabolite prior to extraction is the responsibility of customer, but if rapid changes in concentration are expected, Bevital recommend freeze clamping of tissue or treatment cell pellet with liquid nitrogen. Stability after protein precipitation in extraction solution is expected to be similar for serum/plasma, cells and tissues.

- Assay interference.

Interference from endogenous compounds may differ between different sample matrices. Interference will be considered by inspection of elution profile, mass fragmentation pattern and comparisons of different ion pairs.

- Linearity and dynamic range.

Assessment of linearity is obtained by serial dilution of the extract up to about 30-fold dilution or until Lower Limit of Detection (LOD). In addition, a standard addition procedure should be carried out by adding unlabelled metabolite to obtain a final metabolite concentration of 2 to about 30 times the endogenous levels. An indication of linearity will be obtained by plotting the ratio of ion intensity of metabolite and deuterated internal standard versus dilution for both experiments.

- Analytical recovery and ion suppression.

A measure of analytical recovery will be obtained by comparing metabolite concentrations from the standard addition experiment with concentrations detected by adding the same amounts to the extraction solution, assuming 100 % recovery in the absence of cell/tissue components. Comparison of the absolute ion intensities of metabolites with and without cell/tissue extraction, will give a measure of ion suppression.

- Calibration.

A 3 points calibration curve covering expected metabolite concentrations will be set up either by adding metabolite to the extraction solution, or, in case of substantial ion suppression (> 50 %) or low analytical recovery (< 70 %) to a cell/tissue extract (standard addition method).

- Precision of the assay.

If requested by the customer, assessment of within-day and between-day precision of the method will be done.

- Costs.

The cost for validation and optimization may be difficult to predict, must be covered by customer, and is calculated from man-months required to accomplish tasks 1 to 8. The current rate is 12000 EURO per man-month.

  • BEVITAL is partner in numerous projects. These include two EU projects, “Metabolomic profiles throughout the continuum of colorectal carcinogenesis” (MetaboCCC) and ”Biomarkers related to folate-dependent one-carbon metabolism in CRC recurrence and survival” (FOCUS), and one large multicenter study on lung cancer, organized within the frame of the lung cancer consortium (LC3), funded by US NCI. The latter study includes 11000 cases and controls recruited from 20 centers, in Europe, US, Asia and Australia.

  • Publications last 5 years, involving analyses carried out by BEVITAL.
2016

1. Hughes, C. F., Ward, M., Tracey, F., Hoey, L., Molloy, A. M., Pentieva, K., and McNulty, H. ( 2017) B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study. Nutrients 9

2. Fluge, O., Mella, O., Bruland, O., Risa, K., Dyrstad, S. E., Alme, K., Rekeland, I. G., Sapkota, D., Rosland, G. V., Fossa, A., Ktoridou-Valen, I., Lunde, S., Sorland, K., Lien, K., Herder, I., Thurmer, H., Gotaas, M. E., Baranowska, K. A., Bohnen, L. M., Schafer, C., McCann, A., Sommerfelt, K., Helgeland, L., Ueland, P. M., Dahl, O., and Tronstad, K. J. (2016) Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI insight 1, e89376

3. Haugen, J., Ulak, M., Chandyo, R. K., Henjum, S., Thorne-Lyman, A. L., Ueland, P. M., Midtun, O., Shrestha, P. S., and Strand, T. A. (2016) Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers. Nutrients 8

4. Landaas, E. T., Aarsland, T. I., Ulvik, A., Halmoy, A., Ueland, P. M., and Haavik, J. (2016) Vitamin levels in adults with ADHD. BJPsych open 2, 377-384

5. Bjorke-Monsen, A. L., Ulvik, A., Nilsen, R. M., Midttun, O., Roth, C., Magnus, P., Stoltenberg, C., Vollset, S. E., Reichborn-Kjennerud, T., and Ueland, P. M. (2016) Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study. Nutrients 8

6. Matejcic, M., de Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., Weiderpass, E., Boutron-Ruault, M. C., Cadeau, C., His, M., Cox, D. G., Boeing, H., Fortner, R. T., Kaaks, R., Lagiou, P., Trichopoulou, A., Benetou, V., Tumino, R., Panico, S., Sieri, S., Palli, D., Ricceri, F., Bueno-de-Mesquita, H. B. A., Skeie, G., Amiano, P., Sánchez, M. J., Chirlaque, M. D., Barricarte, A., Quirós, J. R., Buckland, G., van Gils, C. H., Peeters, P. H., Key, T. J., Riboli, E., Gylling, B., Zeleniuch-Jacquotte, A., Gunter, M. J., Romieu, I., and Chajès, V. (2017) Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. Int J Cancer 140, 1246-1259

7. Rotroff, D. M., Joubert, B. R., Marvel, S. W., Haberg, S. E., Wu, M. C., Nilsen, R. M., Ueland, P. M., Nystad, W., London, S. J., and Motsinger-Reif, A. (2016) Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero. BMC genomics 17, 976

8. Ding, Y., Pedersen, E. R., Svingen, G. F., Helgeland, O., Gregory, J. F., Loland, K. H., Meyer, K., Tell, G. S., Ueland, P. M., and Nygard, O. K. (2016) Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial). Circulation. Cardiovascular genetics 9, 541-547

9. Marild, K., Vistnes, M., Tapia, G., Midttun, O., Ueland, P. M., Viken, M. K., Magnus, P., Berg, J. P., Stene, L. C., and Stordal, K. (2017) Midpregnancy and cord blood immunologic biomarkers, HLA genotype, and pediatric celiac disease. The Journal of allergy and clinical immunology 139, 1696-1698

10. Huang, J. Y., Butler, L. M., Midttun, O., Koh, W. P., Ueland, P. M., Wang, R., Jin, A., Gao, Y. T., and Yuan, J. M. (2016) Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations. Cancer causes & control : CCC 27, 1447-1456

11. Fanidi, A., Muller, D. C., Midttun, O., Ueland, P. M., Vollset, S. E., Relton, C., Vineis, P., Weiderpass, E., Skeie, G., Brustad, M., Palli, D., Tumino, R., Grioni, S., Sacerdote, C., Bueno-de-Mesquita, H. B., Peeters, P. H., Boutron-Ruault, M. C., Kvaskoff, M., Cadeau, C., Huerta, J. M., Sanchez, M. J., Agudo, A., Lasheras, C., Quiros, J. R., Chamosa, S., Riboli, E., Travis, R. C., Ward, H., Murphy, N., Khaw, K. T., Trichopoulou, A., Lagiou, P., Papatesta, E. M., Boeing, H., Kuehn, T., Katzke, V., Steffen, A., Johansson, A., Brennan, P., and Johansson, M. (2016) Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep 6, 36017

12. Colomina, J. M., Cavalle-Busquets, P., Fernandez-Roig, S., Sole-Navais, P., Fernandez-Ballart, J. D., Ballesteros, M., Ueland, P. M., Meyer, K., and Murphy, M. M. (2016) Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy. Nutrients 8

13. Midttun, O., McCann, A., Aarseth, O., Krokeide, M., Kvalheim, G., Meyer, K., and Ueland, P. M. (2016) Combined Measurement of 6 Fat-Soluble Vitamins and 26 Water-Soluble Functional Vitamin Markers and Amino Acids in 50 muL of Serum or Plasma by High-Throughput Mass Spectrometry. Anal Chem 88, 10427-10436

14. van Lee, L., Tint, M. T., Aris, I. M., Quah, P. L., Fortier, M. V., Lee, Y. S., Yap, F. K., Saw, S. M., Godfrey, K. M., Gluckman, P. D., Chong, Y. S., Kramer, M. S., and Chong, M. F.-F. (2016) Prospective associations of maternal betaine status with offspring weight and body composition at birth: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study. Am J Clin Nutr 104, 1327-1333

15. Stiksrud, B., Lorvik, K. B., Kvale, D., Mollnes, T. E., Ueland, P. M., Troseid, M., Tasken, K., and Dyrhol-Riise, A. M. (2016) Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts. Journal of acquired immune deficiency syndromes 73, 138-148

16. Ueland, P. M., McCann, A., Midttun, O., and Ulvik, A. (2017) Inflammation, vitamin B6 and related pathways. Mol Aspects Med 53, 10-27

17. El-Heis, S., Crozier, S. R., Robinson, S. M., Harvey, N. C., Cooper, C., Inskip, H. M., and Godfrey, K. M. (2016) Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months. Clin Exp Allergy 46, 1337-1343

18. Deac, O. M., Mills, J. L., Gardiner, C. M., Shane, B., Quinn, L., Midttun, O., McCann, A., Meyer, K., Ueland, P. M., Fan, R., Lu, Z., Brody, L. C., and Molloy, A. M. (2016) Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. J Nutr 146, 1801-1806

19. Myte, R., Gylling, B., Schneede, J., Ueland, P. M., Haggstrom, J., Hultdin, J., Hallmans, G., Johansson, I., Palmqvist, R., and Van Guelpen, B. (2016) Components of One-carbon Metabolism Other than Folate and Colorectal Cancer Risk. Epidemiology 27, 787-796

20. Chandyo, R. K., Ulak, M., Sommerfelt, H., Schneede, J., Ueland, P. M., and Strand, T. A. (2016) Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal. Nutrients 8

21. Reese, S. E., Zhao, S., Wu, M. C., Joubert, B. R., Parr, C. L., Haberg, S. E., Ueland, P. M., Nilsen, R. M., Midttun, O., Vollset, S. E., Peddada, S. D., Nystad, W., and London, S. J. (2017) DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy. Environmental health perspectives 125, 760-766

22. Magnus, M. C., Karlstad, O., Midtun, O., Haberg, S. E., Tunheim, G., Parr, C. L., Nafstad, P., London, S. J., Nilsen, R. M., Ueland, P. M., and Nystad, W. (2016) Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring. The Journal of allergy and clinical immunology 138, 1319-1325 e1314

23. Ulvik, A., Pedersen, E. R., Svingen, G. F., McCann, A., Midttun, O., Nygard, O., and Ueland, P. M. (2016) Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease. Am J Clin Nutr 103, 1417-1425

24. Molloy, A. M., Pangilinan, F., Mills, J. L., Shane, B., O'Neill, M. B., McGaughey, D. M., Velkova, A., Abaan, H. O., Ueland, P. M., McNulty, H., Ward, M., Strain, J. J., Cunningham, C., Casey, M., Cropp, C. D., Kim, Y., Bailey-Wilson, J. E., Wilson, A. F., and Brody, L. C. (2016) A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin. American journal of human genetics 98, 869-882

25. Price, A. J., Travis, R. C., Appleby, P. N., Albanes, D., Barricarte Gurrea, A., Bjorge, T., Bueno-de-Mesquita, H. B., Chen, C., Donovan, J., Gislefoss, R., Goodman, G., Gunter, M., Hamdy, F. C., Johansson, M., King, I. B., Kuhn, T., Mannisto, S., Martin, R. M., Meyer, K., Neal, D. E., Neuhouser, M. L., Nygard, O., Stattin, P., Tell, G. S., Trichopoulou, A., Tumino, R., Ueland, P. M., Ulvik, A., de Vogel, S., Vollset, S. E., Weinstein, S. J., Key, T. J., Allen, N. E., Endogenous Hormones, N. B., and Prostate Cancer Collaborative, G. (2016) Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls. European urology 70, 941-951

26. Ulak, M., Chandyo, R. K., Thorne-Lyman, A. L., Henjum, S., Ueland, P. M., Midttun, O., Shrestha, P. S., Fawzi, W. W., Graybill, L., and Strand, T. A. (2016) Vitamin Status among Breastfed Infants in Bhaktapur, Nepal. Nutrients 8, 149

27. Borgeraas, H., Hertel, J. K., Svingen, G. F. T., Pedersen, E. R., Seifert, R., Nygård, O., and Hjelmesæth, J. (2016) Association between Body Mass Index, Asymmetric Dimethylarginine and Risk of Cardiovascular Events and Mortality in Norwegian Patients with Suspected Stable Angina Pectoris. PLoS One 11, e0152029

28. Svingen, G. F., Schartum-Hansen, H., Pedersen, E. R., Ueland, P. M., Tell, G. S., Mellgren, G., Njolstad, P. R., Seifert, R., Strand, E., Karlsson, T., and Nygard, O. (2016) Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes. Clinical chemistry 62, 755-765

29. Borgeraas, H., Hertel, J. K., Seifert, R., Berge, R. K., Bohov, P., Ueland, P. M., Nygard, O., and Hjelmesaeth, J. (2016) Serum trans fatty acids, asymmetric dimethylarginine and risk of acute myocardial infarction and mortality in patients with suspected coronary heart disease: a prospective cohort study. Lipids Health Dis 15, 38

30. Chuang, S. C., Boeing, H., Vollset, S. E., Midttun, O., Ueland, P. M., Bueno-de-Mesquita, B., Lajous, M., Fagherazzi, G., Boutron-Ruault, M. C., Kaaks, R., Kuehn, T., Pischon, T., Drogan, D., Tjonneland, A., Overvad, K., Quiros, J. R., Agudo, A., Molina-Montes, E., Dorronsoro, M., Huerta, J. M., Barricarte, A., Khaw, K. T., Wareham, N. J., Travis, R. C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Masala, G., Agnoli, C., Tumino, R., Mattiello, A., Peeters, P. H., Weiderpass, E., Palmqvist, R., Ljuslinder, I., Gunter, M., Lu, Y., Cross, A. J., Riboli, E., Vineis, P., and Aleksandrova, K. (2016) Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study. Immunity & ageing : I & A 13, 5

31. Joubert, B. R., den Dekker, H. T., Felix, J. F., Bohlin, J., Ligthart, S., Beckett, E., Tiemeier, H., van Meurs, J. B., Uitterlinden, A. G., Hofman, A., Haberg, S. E., Reese, S. E., Peters, M. J., Andreassen, B. K., Steegers, E. A., Nilsen, R. M., Vollset, S. E., Midttun, O., Ueland, P. M., Franco, O. H., Dehghan, A., de Jongste, J. C., Wu, M. C., Wang, T., Peddada, S. D., Jaddoe, V. W., Nystad, W., Duijts, L., and London, S. J. (2016) Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nature communications 7, 10577

32. Zuo, H., Ueland, P. M., Ulvik, A., Eussen, S. J., Vollset, S. E., Nygard, O., Midttun, O., Theofylaktopoulou, D., Meyer, K., and Tell, G. S. (2016) Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study. American journal of epidemiology 183, 249-258

33. Ding, Y. P., Pedersen, E. K., Johansson, S., Gregory, J. F., 3rd, Ueland, P. M., Svingen, G. F., Helgeland, O., Meyer, K., Fredriksen, A., and Nygard, O. K. (2016) B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. Nutrition, metabolism, and cardiovascular diseases : NMCD 26, 495-501

34. Vaish, S., White, M., Daly, L., Molloy, A. M., Staines, A., and Sweeney, M. R. (2016) Synthetic folic acid intakes and status in children living in Ireland exposed to voluntary fortification. Am J Clin Nutr 103, 512-518

35. Lysne, V., Strand, E., Svingen, G. F., Bjorndal, B., Pedersen, E. R., Midttun, O., Olsen, T., Ueland, P. M., Berge, R. K., and Nygard, O. (2016) Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. Nutrients 8

36. Degerud, E., Hoff, R., Nygard, O., Strand, E., Nilsen, D. W., Nordrehaug, J. E., Midttun, O., Ueland, P. M., de Vogel, S., and Dierkes, J. (2016) Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway. Eur J Clin Nutr 70, 517-522

37. Bueno, O., Molloy, A. M., Fernandez-Ballart, J. D., Garcia-Minguillan, C. J., Ceruelo, S., Rios, L., Ueland, P. M., Meyer, K., and Murphy, M. M. (2016) Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status. J Nutr 146, 1-8

38. Zwart, S. R., Gregory, J. F., Zeisel, S. H., Gibson, C. R., Mader, T. H., Kinchen, J. M., Ueland, P. M., Ploutz-Snyder, R., Heer, M. A., and Smith, S. M. (2016) Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30, 141-148

2015

1. Ding, Y. P., Pedersen, E. K., Johansson, S., Gregory, J. F., 3rd, Ueland, P. M., Svingen, G. F., Helgeland, O., Meyer, K., Fredriksen, A., and Nygard, O. K. (2016) B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. Nutrition, metabolism, and cardiovascular diseases : NMCD 26, 495-501

2. Ding, Y., Svingen, G. F., Pedersen, E. R., Gregory, J. F., Ueland, P. M., Tell, G. S., and Nygard, O. K. (2015) Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris. J Am Heart Assoc 5

3. Torsvik, I. K., Ueland, P. M., Markestad, T., Midttun, O., and Bjorke Monsen, A. L. (2015) Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial. BMC pediatrics 15, 218

4. Degerud, E., Hoff, R., Nygard, O., Strand, E., Nilsen, D. W., Nordrehaug, J. E., Midttun, O., Ueland, P. M., de Vogel, S., and Dierkes, J. (2016) Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway. Eur J Clin Nutr 70, 517-522

5. Bueno, O., Molloy, A. M., Fernandez-Ballart, J. D., Garcia-Minguillan, C. J., Ceruelo, S., Rios, L., Ueland, P. M., Meyer, K., and Murphy, M. M. (2016) Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status. J Nutr 146, 1-8

6. Aarsland, T. I., Landaas, E. T., Hegvik, T. A., Ulvik, A., Halmoy, A., Ueland, P. M., and Haavik, J. (2015) Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case-control study. Behavioral and brain functions : BBF 11, 36

7. Muller, D. C., Johansson, M., Zaridze, D., Moukeria, A., Janout, V., Holcatova, I., Navratilova, M., Mates, D., Midttun, O., Ueland, P. M., Brennan, P., and Scelo, G. (2015) Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study. PLoS One 10, e0140677

8. Karlsson, T., Strand, E., Dierkes, J., Drevon, C. A., Oyen, J., Midttun, O., Ueland, P. M., Gudbrandsen, O. A., Pedersen, E. R., and Nygard, O. (2017) Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease. Eur J Nutr 56, 261-272

9. Gaardbo, J. C., Trosied, M., Stiksrud, B., Midttun, O., Ueland, P. M., Ullum, H., and Nielsen, S. D. (2015) Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up. Journal of acquired immune deficiency syndromes 70, 228-235

10. Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., 3rd, Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., Molloy, A. M., Caudill, M. A., Shane, B., Berry, R. J., Bailey, R. L., Hausman, D. B., Raghavan, R., and Raiten, D. J. (2015) Biomarkers of Nutrition for Development-Folate Review. J Nutr 145, 1636S-1680S

11. Lehmann, U., Gjessing, H. R., Hirche, F., Mueller-Belecke, A., Gudbrandsen, O. A., Ueland, P. M., Mellgren, G., Lauritzen, L., Lindqvist, H., Hansen, A. L., Erkkila, A. T., Pot, G. K., Stangl, G. I., and Dierkes, J. (2015) Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials. Am J Clin Nutr 102, 837-847

12. Zwart, S. R., Gregory, J. F., Zeisel, S. H., Gibson, C. R., Mader, T. H., Kinchen, J. M., Ueland, P. M., Ploutz-Snyder, R., Heer, M. A., and Smith, S. M. (2016) Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30, 141-148

13. Stiksrud, B., Nowak, P., Nwosu, F. C., Kvale, D., Thalme, A., Sonnerborg, A., Ueland, P. M., Holm, K., Birkeland, S. E., Dahm, A. E., Sandset, P. M., Rudi, K., Hov, J. R., Dyrhol-Riise, A. M., and Troseid, M. (2015) Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART. Journal of acquired immune deficiency syndromes 70, 329-337

14. Rios-Avila, L., Coats, B., Ralat, M., Chi, Y. Y., Midttun, O., Ueland, P. M., Stacpoole, P. W., and Gregory, J. F., 3rd. (2015) Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users. Am J Clin Nutr 102, 616-625

15. Gaardbo, J. C., Troseid, M., Stiksrud, B., Midttun, O., Ueland, P. M., Ullum, H., and Nielsen, S. D. (2015) Increased Tryptophan Catabolism is Associated with Increased Frequency of CD161+Tc17/MAIT Cells, and Lower CD4+ T cell Count in HIV-1 infected Patients on cART after Two Years of Follow-up. Journal of acquired immune deficiency syndromes

16. Skeie, E., Strand, E., Pedersen, E. R., Bjorndal, B., Bohov, P., Berge, R. K., Svingen, G. F., Seifert, R., Ueland, P. M., Midttun, O., Ulvik, A., Hustad, S., Drevon, C. A., Gregory, J. F., and Nygard, O. (2015) Circulating B-vitamins and smoking habits are associated with serum polyunsaturated Fatty acids in patients with suspected coronary heart disease: a cross-sectional study. PLoS One 10, e0129049

17. Muller, D. C., Scelo, G., Zaridze, D., Janout, V., Holcatova, I., Navratilova, M., Mates, D., Midttun, O., Ueland, P. M., Brennan, P., and Johansson, M. (2015) Circulating 25-hydroxyvitamin D3 and survival after diagnosis with kidney cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 24, 1277-1281

18. Ueland, P. M., Ulvik, A., Rios-Avila, L., Midttun, O., and Gregory, J. F. (2015) Direct and Functional Biomarkers of Vitamin B6 Status. Annual review of nutrition 35, 33-70

19. Carter, T. C., Pangilinan, F., Molloy, A. M., Fan, R., Wang, Y., Shane, B., Gibney, E. R., Midttun, O., Ueland, P. M., Cropp, C. D., Kim, Y., Wilson, A. F., Bailey-Wilson, J. E., Brody, L. C., and Mills, J. L. (2015) Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults. J Nutr 145, 1386-1393

20. Eussen, S. J., Ueland, P. M., Vollset, S. E., Nygard, O., Midttun, O., Sulo, G., Ulvik, A., Meyer, K., Pedersen, E. R., and Tell, G. S. (2015) Kynurenines as predictors of acute coronary events in the Hordaland Health Study. International journal of cardiology 189, 18-24

21. Deac, O. M., Mills, J. L., Shane, B., Midttun, O., Ueland, P. M., Brosnan, J. T., Brosnan, M. E., Laird, E., Gibney, E. R., Fan, R., Wang, Y., Brody, L. C., and Molloy, A. M. (2015) Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr 145, 701-707

22. Rebnord, E. W., Pedersen, E. R., Strand, E., Svingen, G. F., Meyer, K., Schartum-Hansen, H., Loland, K. H., Seifert, R., Ueland, P. M., Nilsen, D. W., Nordrehaug, J. E., and Nygard, O. (2015) Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: a prospective cohort study. Atherosclerosis 240, 115-120

23. Aleksandrova, K., Chuang, S. C., Boeing, H., Zuo, H., Tell, G. S., Pischon, T., Jenab, M., Bueno-de-Mesquita, B., Vollset, S. E., Midttun, O., Ueland, P. M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M. C., Kaaks, R., Kuhn, T., Tjonneland, A., Overvad, K., Quiros, J. R., Jakszyn, P., Sanchez, M. J., Dorronsoro, M., Chirlaque, M. D., Ardanaz, E., Khaw, K. T., Wareham, N. J., Travis, R. C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Tumino, R., Panico, S., May, A. M., Palmqvist, R., Ljuslinder, I., Kong, S. Y., Freisling, H., Gunter, M. J., Lu, Y., Cross, A. J., Riboli, E., and Vineis, P. (2015) A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk. Journal of the National Cancer Institute 107

24. Oyen, J., Svingen, G. F., Gjesdal, C. G., Tell, G. S., Ueland, P. M., Lysne, V., Apalset, E. M., Meyer, K., Vollset, S. E., and Nygard, O. K. (2015) Plasma dimethylglycine, nicotine exposure and risk of low bone mineral density and hip fracture: the Hordaland Health Study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 26, 1573-1583

25. Keaveney, E. M., Price, R. K., Hamill, L. L., Wallace, J. M., McNulty, H., Ward, M., Strain, J. J., Ueland, P. M., Molloy, A. M., Piironen, V., von Reding, W., Shewry, P. R., Ward, J. L., and Welch, R. W. (2015) Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread. Br J Nutr 113, 445-453

26. Rios-Avila, L., Coats, B., Chi, Y. Y., Midttun, O., Ueland, P. M., Stacpoole, P. W., and Gregory, J. F., 3rd. (2015) Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes. J Nutr 145, 87-95

27. Pedersen, E. R., Tuseth, N., Eussen, S. J., Ueland, P. M., Strand, E., Svingen, G. F., Midttun, O., Meyer, K., Mellgren, G., Ulvik, A., Nordrehaug, J. E., Nilsen, D. W., and Nygard, O. (2015) Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, thrombosis, and vascular biology 35, 455-462

28. Zuo, H., Ueland, P. M., Eussen, S. J., Tell, G. S., Vollset, S. E., Nygard, O., Midttun, O., Meyer, K., and Ulvik, A. (2015) Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study. Int J Cancer 136, 2932-2939

29. Fanidi, A., Relton, C., Ueland, P. M., Midttun, O., Vollset, S. E., Travis, R. C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Bueno-de-Mesquita, H. B., Ros, M., Boeing, H., Tumino, R., Panico, S., Palli, D., Sieri, S., Vineis, P., Sanchez, M. J., Huerta, J. M., Barricarte Gurrea, A., Lujan-Barroso, L., Quiros, J. R., Tjonneland, A., Halkjaer, J., Boutron-Ruault, M. C., Clavel-Chapelon, F., Cadeau, C., Weiderpass, E., Johansson, M., Riboli, E., Brennan, P., and Johansson, M. (2015) A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus. Int J Cancer 136, 915-927

30. Svingen, G. F., Schartum-Hansen, H., Ueland, P. M., Pedersen, E. R., Seifert, R., Ebbing, M., Bonaa, K. H., Mellgren, G., Nilsen, D. W., Nordrehaug, J. E., Oyen, J., and Nygard, O. (2015) Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European journal of preventive cardiology 22, 743-752

31. Schartum-Hansen, H., Pedersen, E. R., Svingen, G. F., Ueland, P. M., Seifert, R., Ebbing, M., Strand, E., Bleie, O., and Nygard, O. (2015) Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris. European journal of preventive cardiology 22, 606-614

32. Degerud, E., Loland, K. H., Nygard, O., Midttun, O., Ueland, P. M., Seifert, R., Strand, E., Bleie, O., and Dierkes, J. (2015) Vitamin D status was not associated with 'one-year' progression of coronary artery disease, assessed by coronary angiography in statin-treated patients. European journal of preventive cardiology 22, 594-602

2014

1. Rios-Avila, L., Coats, B., Chi, Y. Y., Midttun, O., Ueland, P. M., Stacpoole, P. W., and Gregory, J. F., 3rd. (2015) Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes. J Nutr 145, 87-95

2. Pedersen, E. R., Tuseth, N., Eussen, S. J., Ueland, P. M., Strand, E., Svingen, G. F., Midttun, O., Meyer, K., Mellgren, G., Ulvik, A., Nordrehaug, J. E., Nilsen, D. W., and Nygard, O. (2015) Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, thrombosis, and vascular biology 35, 455-462

3. Zuo, H., Ueland, P. M., Eussen, S. J., Tell, G. S., Vollset, S. E., Nygard, O., Midttun, O., Meyer, K., and Ulvik, A. (2015) Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study. Int J Cancer 136, 2932-2939

4. Johansson, M., Fanidi, A., Muller, D. C., Bassett, J. K., Midttun, O., Vollset, S. E., Travis, R. C., Palli, D., Mattiello, A., Sieri, S., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Ljungberg, B., Hallmans, G., Weiderpass, E., Skeie, G., Gonzalez, C. A., Dorronsoro, M., Peeters, P. H., Bueno-de-Mesquita, H. B., Ros, M. M., Boutron Ruault, M. C., Fagherazzi, G., Clavel, F., Sanchez, M. J., Gurrea, A. B., Navarro, C., Quiros, J. R., Overvad, K., Tjonneland, A., Aleksandrova, K., Vineis, P., Gunter, M. J., Kaaks, R., Giles, G., Relton, C., Riboli, E., Boeing, H., Ueland, P. M., Severi, G., and Brennan, P. (2014) Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival. Journal of the National Cancer Institute 106

5. Garcia-Minguillan, C. J., Fernandez-Ballart, J. D., Ceruelo, S., Rios, L., Bueno, O., Berrocal-Zaragoza, M. I., Molloy, A. M., Ueland, P. M., Meyer, K., and Murphy, M. M. (2014) Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine. Genes & nutrition 9, 435

6. Mills, J. L., Fan, R., Brody, L. C., Liu, A., Ueland, P. M., Wang, Y., Kirke, P. N., Shane, B., and Molloy, A. M. (2014) Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. Am J Clin Nutr 100, 1069-1074

7. Muller, D. C., Fanidi, A., Midttun, O., Steffen, A., Dossus, L., Boutron-Ruault, M. C., Severi, G., Kuhn, T., Katzke, V., de la Torre, R. A., Gonzalez, C. A., Sanchez, M. J., Dorronsoro, M., Santiuste, C., Barricarte, A., Khaw, K. T., Wareham, N., Travis, R. C., Trichopoulou, A., Giotaki, M., Trichopoulos, D., Palli, D., Krogh, V., Tumino, R., Vineis, P., Panico, S., Tjonneland, A., Olsen, A., Bueno-de-Mesquita, H. B., Peeters, P. H., Ljungberg, B., Wennberg, M., Weiderpass, E., Murphy, N., Riboli, E., Ueland, P. M., Boeing, H., Brennan, P., and Johansson, M. (2014) Circulating 25-hydroxyvitamin D3 in relation to renal cell carcinoma incidence and survival in the EPIC cohort. American journal of epidemiology 180, 810-820

8. Theofylaktopoulou, D., Ulvik, A., Midttun, O., Ueland, P. M., Vollset, S. E., Nygard, O., Hustad, S., Tell, G. S., and Eussen, S. J. (2014) Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-gamma-mediated immune activation in the community-based Hordaland Health Study. Br J Nutr 112, 1065-1072

9. Gylling, B., Van Guelpen, B., Schneede, J., Hultdin, J., Ueland, P. M., Hallmans, G., Johansson, I., and Palmqvist, R. (2014) Low folate levels are associated with reduced risk of colorectal cancer in a population with low folate status. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23, 2136-2144

10. Fanidi, A., Relton, C., Ueland, P. M., Midttun, O., Vollset, S. E., Travis, R. C., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Bueno-de-Mesquita, H. B., Ros, M., Boeing, H., Tumino, R., Panico, S., Palli, D., Sieri, S., Vineis, P., Sanchez, M. J., Huerta, J. M., Barricarte Gurrea, A., Lujan-Barroso, L., Quiros, J. R., Tjonneland, A., Halkjaer, J., Boutron-Ruault, M. C., Clavel-Chapelon, F., Cadeau, C., Weiderpass, E., Johansson, M., Riboli, E., Brennan, P., and Johansson, M. (2015) A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus. Int J Cancer 136, 915-927

11. Zuo, H., Tell, G. S., Vollset, S. E., Ueland, P. M., Nygard, O., Midttun, O., Meyer, K., Ulvik, A., and Eussen, S. J. (2014) Interferon-gamma-induced inflammatory markers and the risk of cancer: the Hordaland Health Study. Cancer 120, 3370-3377

12. Meyer, K., and Ueland, P. M. (2014) Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS. Anal Chem 86, 5807-5814

13. Nitter, M., Norgard, B., de Vogel, S., Eussen, S. J., Meyer, K., Ulvik, A., Ueland, P. M., Nygard, O., Vollset, S. E., Bjorge, T., Tjonneland, A., Hansen, L., Boutron-Ruault, M., Racine, A., Cottet, V., Kaaks, R., Kuhn, T., Trichopoulou, A., Bamia, C., Naska, A., Grioni, S., Palli, D., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., van Kranen, H., Peeters, P. H., Weiderpass, E., Dorronsoro, M., Jakszyn, P., Sanchez, M., Arguelles, M., Huerta, J. M., Barricarte, A., Johansson, M., Ljuslinder, I., Khaw, K., Wareham, N., Freisling, H., Duarte-Salles, T., Stepien, M., Gunter, M. J., and Riboli, E. (2014) Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Annals of oncology : official journal of the European Society for Medical Oncology 25, 1609-1615

14. Apalset, E. M., Gjesdal, C. G., Ueland, P. M., Oyen, J., Meyer, K., Midttun, O., Eide, G. E., and Tell, G. S. (2014) Interferon gamma (IFN-gamma)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: the Hordaland Health Study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 25, 2067-2075

15. Ulvik, A., Midttun, O., Pedersen, E. R., Eussen, S. J., Nygard, O., and Ueland, P. M. (2014) Evidence for increased catabolism of vitamin B-6 during systemic inflammation. Am J Clin Nutr 100, 250-255

16. Joubert, B. R., Haberg, S. E., Bell, D. A., Nilsen, R. M., Vollset, S. E., Midttun, O., Ueland, P. M., Wu, M. C., Nystad, W., Peddada, S. D., and London, S. J. (2014) Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance? Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23, 1007-1017

17. Svingen, G. F., Schartum-Hansen, H., Ueland, P. M., Pedersen, E. R., Seifert, R., Ebbing, M., Bonaa, K. H., Mellgren, G., Nilsen, D. W., Nordrehaug, J. E., Oyen, J., and Nygard, O. (2015) Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. European journal of preventive cardiology 22, 743-752

18. Oyen, J., Gram Gjesdal, C., Nygard, O. K., Lie, S. A., Meyer, H. E., Apalset, E. M., Ueland, P. M., Pedersen, E. R., Midttun, O., Vollset, S. E., and Tell, G. S. (2014) Smoking and body fat mass in relation to bone mineral density and hip fracture: the Hordaland Health Study. PLoS One 9, e92882

19. Midttun, O., Townsend, M. K., Nygard, O., Tworoger, S. S., Brennan, P., Johansson, M., and Ueland, P. M. (2014) Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and cardiovascular patients. J Nutr 144, 784-790

20. Schartum-Hansen, H., Pedersen, E. R., Svingen, G. F., Ueland, P. M., Seifert, R., Ebbing, M., Strand, E., Bleie, O., and Nygard, O. (2015) Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris. European journal of preventive cardiology 22, 606-614

21. Engel, S. M., Joubert, B. R., Wu, M. C., Olshan, A. F., Haberg, S. E., Ueland, P. M., Nystad, W., Nilsen, R. M., Vollset, S. E., Peddada, S. D., and London, S. J. (2014) Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort. American journal of epidemiology 179, 834-842

22. Shaw, G. M., Yang, W., Carmichael, S. L., Vollset, S. E., Hobbs, C. A., Lammer, E. J., and Ueland, P. M. (2014) One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects. Birth defects research. Part A, Clinical and molecular teratology 100, 107-115

23. Apalset, E. M., Gjesdal, C. G., Ueland, P. M., Midttun, O., Ulvik, A., Eide, G. E., Meyer, K., and Tell, G. S. (2014) Interferon (IFN)-gamma-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study. Clinical and experimental immunology 176, 452-460

24. Nilsen, R. M., Mastroiacovo, P., Gunnes, N., Alsaker, E. R., Bjorke-Monsen, A. L., Eussen, S. J., Haugen, M., Johannessen, A., Meltzer, H. M., Stoltenberg, C., Ueland, P. M., and Vollset, S. E. (2014) Folic acid supplementation and interpregnancy interval. Paediatric and perinatal epidemiology 28, 270-274

25. Degerud, E., Loland, K. H., Nygard, O., Midttun, O., Ueland, P. M., Seifert, R., Strand, E., Bleie, O., and Dierkes, J. (2015) Vitamin D status was not associated with 'one-year' progression of coronary artery disease, assessed by coronary angiography in statin-treated patients. European journal of preventive cardiology 22, 594-602

26. Chuang, S. C., Fanidi, A., Ueland, P. M., Relton, C., Midttun, O., Vollset, S. E., Gunter, M. J., Seckl, M. J., Travis, R. C., Wareham, N., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Peeters, P. H., Bueno-de-Mesquita, H. B., Boeing, H., Wientzek, A., Kuehn, T., Kaaks, R., Tumino, R., Agnoli, C., Palli, D., Naccarati, A., Aicua, E. A., Sanchez, M. J., Quiros, J. R., Chirlaque, M. D., Agudo, A., Johansson, M., Grankvist, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Weiderpass, E., Riboli, E., Brennan, P. J., Vineis, P., and Johansson, M. (2014) Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23, 461-468

27. Doets, E. L., Ueland, P. M., Tell, G. S., Vollset, S. E., Nygard, O. K., Van't Veer, P., de Groot, L. C., Nurk, E., Refsum, H., Smith, A. D., and Eussen, S. J. (2014) Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study. Br J Nutr 111, 1085-1095

28. de Vogel, S., Ulvik, A., Meyer, K., Ueland, P. M., Nygard, O., Vollset, S. E., Tell, G. S., Gregory, J. F., 3rd, Tretli, S., and Bjorge, T. (2014) Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway. Int J Cancer 134, 197-206

29. Oyen, J., Nygard, O. K., Gjesdal, C. G., Ueland, P. M., Apalset, E. M., Schartum-Hansen, H., Vollset, S. E., Meyer, K., and Tell, G. S. (2014) Plasma choline, nicotine exposure, and risk of low bone mineral density and hip fracture: the Hordaland health study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 29, 242-250

2013

1. Chuang, S. C., Fanidi, A., Ueland, P. M., Relton, C., Midttun, O., Vollset, S. E., Gunter, M. J., Seckl, M. J., Travis, R. C., Wareham, N., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Peeters, P. H., Bueno-de-Mesquita, H. B., Boeing, H., Wientzek, A., Kuehn, T., Kaaks, R., Tumino, R., Agnoli, C., Palli, D., Naccarati, A., Aicua, E. A., Sanchez, M. J., Quiros, J. R., Chirlaque, M. D., Agudo, A., Johansson, M., Grankvist, K., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Weiderpass, E., Riboli, E., Brennan, P. J., Vineis, P., and Johansson, M. (2014) Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23, 461-468

2. Doets, E. L., Ueland, P. M., Tell, G. S., Vollset, S. E., Nygard, O. K., Van't Veer, P., de Groot, L. C., Nurk, E., Refsum, H., Smith, A. D., and Eussen, S. J. (2014) Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study. Br J Nutr 111, 1085-1095

3. Vinknes, K. J., Dekker, J. M., Drevon, C. A., Refsum, H., Nurk, E., Nijpels, G., Stehouwer, C. D., Teerlink, T., Tell, G. S., Nygard, O., Vollset, S. E., Ueland, P. M., and Elshorbagy, A. K. (2013) Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations. Prostaglandins, leukotrienes, and essential fatty acids 89, 297-303

4. Storm, C., Danne, O., Ueland, P. M., Leithner, C., Hasper, D., and Schroeder, T. (2013) Serial plasma choline measurements after cardiac arrest in patients undergoing mild therapeutic hypothermia: a prospective observational pilot trial. PLoS One 8, e76720

5. Torsvik, I., Ueland, P. M., Markestad, T., and Bjorke-Monsen, A. L. (2013) Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study. Am J Clin Nutr 98, 1233-1240

6. Ulvik, A., Theofylaktopoulou, D., Midttun, O., Nygard, O., Eussen, S. J., and Ueland, P. M. (2013) Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status. Am J Clin Nutr 98, 934-940

7. da Silva, V. R., Rios-Avila, L., Lamers, Y., Ralat, M. A., Midttun, O., Quinlivan, E. P., Garrett, T. J., Coats, B., Shankar, M. N., Percival, S. S., Chi, Y. Y., Muller, K. E., Ueland, P. M., Stacpoole, P. W., and Gregory, J. F., 3rd. (2013) Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women. J Nutr 143, 1719-1727

8. Cope, E. L., Shrubsole, M. J., Cohen, S. S., Cai, Q., Wu, J., Ueland, P. M., Midttun, O., Sonderman, J. S., Blot, W. J., and Signorello, L. B. (2013) Intraindividual variation in one-carbon metabolism plasma biomarkers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 22, 1894-1899

9. Schartum-Hansen, H., Ueland, P. M., Pedersen, E. R., Meyer, K., Ebbing, M., Bleie, O., Svingen, G. F., Seifert, R., Vikse, B. E., and Nygard, O. (2013) Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients. PLoS One 8, e69454

10. Loland, K. H., Bleie, O., Strand, E., Ueland, P. M., Nordrehaug, J. E., Garcia-Garcia, H. M., Serruys, P. W., and Nygard, O. (2013) Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. PLoS One 8, e70101

11. Sandvik, M. K., Leirgul, E., Nygard, O., Ueland, P. M., Berg, A., Svarstad, E., and Vikse, B. E. (2013) Preeclampsia in healthy women and endothelial dysfunction 10 years later. American journal of obstetrics and gynecology 209, 569 e561-569 e510

12. Pedersen, E. R., Svingen, G. F., Schartum-Hansen, H., Ueland, P. M., Ebbing, M., Nordrehaug, J. E., Igland, J., Seifert, R., Nilsen, R. M., and Nygard, O. (2013) Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography. Eur Heart J 34, 2689-2696

13. Shenker, N. S., Ueland, P. M., Polidoro, S., van Veldhoven, K., Ricceri, F., Brown, R., Flanagan, J. M., and Vineis, P. (2013) DNA methylation as a long-term biomarker of exposure to tobacco smoke. Epidemiology 24, 712-716

14. Chuang, S. C., Rota, M., Gunter, M. J., Zeleniuch-Jacquotte, A., Eussen, S. J., Vollset, S. E., Ueland, P. M., Norat, T., Ziegler, R. G., and Vineis, P. (2013) Quantifying the dose-response relationship between circulating folate concentrations and colorectal cancer in cohort studies: a meta-analysis based on a flexible meta-regression model. American journal of epidemiology 178, 1028-1037

15. van Meurs, J. B., Pare, G., Schwartz, S. M., Hazra, A., Tanaka, T., Vermeulen, S. H., Cotlarciuc, I., Yuan, X., Malarstig, A., Bandinelli, S., Bis, J. C., Blom, H., Brown, M. J., Chen, C., Chen, Y. D., Clarke, R. J., Dehghan, A., Erdmann, J., Ferrucci, L., Hamsten, A., Hofman, A., Hunter, D. J., Goel, A., Johnson, A. D., Kathiresan, S., Kampman, E., Kiel, D. P., Kiemeney, L. A., Chambers, J. C., Kraft, P., Lindemans, J., McKnight, B., Nelson, C. P., O'Donnell, C. J., Psaty, B. M., Ridker, P. M., Rivadeneira, F., Rose, L. M., Seedorf, U., Siscovick, D. S., Schunkert, H., Selhub, J., Ueland, P. M., Vollenweider, P., Waeber, G., Waterworth, D. M., Watkins, H., Witteman, J. C., den Heijer, M., Jacques, P., Uitterlinden, A. G., Kooner, J. S., Rader, D. J., Reilly, M. P., Mooser, V., Chasman, D. I., Samani, N. J., and Ahmadi, K. R. (2013) Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr 98, 668-676

16. de Vogel, S., Ulvik, A., Meyer, K., Ueland, P. M., Nygard, O., Vollset, S. E., Tell, G. S., Gregory, J. F., 3rd, Tretli, S., and Bjorge, T. (2014) Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway. Int J Cancer 134, 197-206

17. Jenssen, H. B., Torsvik, I., Ueland, P. M., Midttun, O., and Bjorke-Monsen, A. L. (2013) Biochemical signs of impaired cobalamin function do not affect hematological parameters in young infants: results from a double-blind randomized controlled trial. Pediatric research 74, 327-332

18. Loland, K. H., Bleie, O., Borgeraas, H., Strand, E., Ueland, P. M., Svardal, A., Nordrehaug, J. E., and Nygard, O. (2013) The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine. PLoS One 8, e64774

19. Svingen, G. F., Ueland, P. M., Pedersen, E. K., Schartum-Hansen, H., Seifert, R., Ebbing, M., Loland, K. H., Tell, G. S., and Nygard, O. (2013) Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, thrombosis, and vascular biology 33, 2041-2048

20. Theofylaktopoulou, D., Midttun, O., Ulvik, A., Ueland, P. M., Tell, G. S., Vollset, S. E., Nygard, O., and Eussen, S. J. (2013) A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. Clinical and experimental immunology 173, 121-130

21. Fernandez-Roig, S., Cavalle-Busquets, P., Fernandez-Ballart, J. D., Ballesteros, M., Berrocal-Zaragoza, M. I., Salat-Batlle, J., Ueland, P. M., and Murphy, M. M. (2013) Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine. Am J Clin Nutr 97, 1252-1259

22. Paul, L., Ueland, P. M., and Selhub, J. (2013) Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation. Nutrition reviews 71, 239-244

23. Baltar, V. T., Xun, W. W., Johansson, M., Ferrari, P., Chuang, S. C., Relton, C., Ueland, P. M., Midttun, O., Slimani, N., Jenab, M., Clavel-Chapelon, F., Boutron-Ruault, M. C., Fagherazzi, G., Kaaks, R., Rohrmann, S., Boeing, H., Weikert, C., Bueno-de-Mesquita, B., Boshuizen, H., van Gils, C. H., Onland-Moret, N. C., Agudo, A., Barricarte, A., Navarro, C., Rodriguez, L., Castano, J. M., Larranaga, N., Khaw, K. T., Wareham, N., Allen, N. E., Crowe, F., Gallo, V., Norat, T., Krogh, V., Masala, G., Panico, S., Sacerdote, C., Tumino, R., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Rasmuson, T., Hallmans, G., Roswall, N., Tjonneland, A., Riboli, E., Brennan, P., and Vineis, P. (2013) A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk. Eur J Epidemiol 28, 677-688

24. de Vogel, S., Meyer, K., Fredriksen, A., Ulvik, A., Ueland, P. M., Nygard, O., Vollset, S. E., Tell, G. S., Tretli, S., and Bjorge, T. (2013) Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort. International journal of epidemiology 42, 201-210

25. Hogeveen, M., den Heijer, M., Semmekrot, B. A., Sporken, J. M., Ueland, P. M., and Blom, H. J. (2013) Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight. Pediatric research 73, 783-787

26. Vollset, S. E., Clarke, R., Lewington, S., Ebbing, M., Halsey, J., Lonn, E., Armitage, J., Manson, J. E., Hankey, G. J., Spence, J. D., Galan, P., Bonaa, K. H., Jamison, R., Gaziano, J. M., Guarino, P., Baron, J. A., Logan, R. F., Giovannucci, E. L., den Heijer, M., Ueland, P. M., Bennett, D., Collins, R., Peto, R., and Collaboration, B. V. T. T. (2013) Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet 381, 1029-1036

27. Sulo, G., Vollset, S. E., Nygard, O., Midttun, O., Ueland, P. M., Eussen, S. J., Pedersen, E. R., and Tell, G. S. (2013) Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study. International journal of cardiology 168, 1435-1440

28. Strain, J. J., McSorley, E. M., van Wijngaarden, E., Kobrosly, R. W., Bonham, M. P., Mulhern, M. S., McAfee, A. J., Davidson, P. W., Shamlaye, C. F., Henderson, J., Watson, G. E., Thurston, S. W., Wallace, J. M., Ueland, P. M., and Myers, G. J. (2013) Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. Br J Nutr 110, 330-336

29. Strand, T. A., Taneja, S., Ueland, P. M., Refsum, H., Bahl, R., Schneede, J., Sommerfelt, H., and Bhandari, N. (2013) Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. Am J Clin Nutr 97, 310-317

30. Midttun, O., Kvalheim, G., and Ueland, P. M. (2013) High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS. Anal Bioanal Chem 405, 2009-2017

31. Eussen, S. J., Nilsen, R. M., Midttun, O., Hustad, S., N, I. J., Meyer, K., Fredriksen, A., Ulvik, A., Ueland, P. M., Brennan, P., Johansson, M., Bueno-de-Mesquita, B., Vineis, P., Chuang, S. C., Boutron-Ruault, M. C., Dossus, L., Perquier, F., Overvad, K., Teucher, B., Grote, V. A., Trichopoulou, A., Adarakis, G., Plada, M., Sieri, S., Tumino, R., de Magistris, M. S., Ros, M. M., Peeters, P. H., Redondo, M. L., Zamora-Ros, R., Chirlaque, M. D., Ardanaz, E., Sonestedt, E., Ericson, U., Schneede, J., van Guelpen, B., Wark, P. A., Gallo, V., Norat, T., Riboli, E., and Vollset, S. E. (2013) North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Br J Nutr 110, 363-374

32. Vogiatzoglou, A., Smith, A. D., Nurk, E., Drevon, C. A., Ueland, P. M., Vollset, S. E., Nygaard, H. A., Engedal, K., Tell, G. S., and Refsum, H. (2013) Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E epsilon4: the Hordaland Homocysteine Study. Psychosomatic medicine 75, 20-29

33. Torsvik, I. K., Markestad, T., Ueland, P. M., Nilsen, R. M., Midttun, O., and Bjorke Monsen, A. L. (2013) Evaluating iron status and the risk of anemia in young infants using erythrocyte parameters. Pediatric research 73, 214-220

34. Jung, A. Y., Botma, A., Lute, C., Blom, H. J., Ueland, P. M., Kvalheim, G., Midttun, O., Nagengast, F., Steegenga, W., and Kampman, E. (2013) Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas. Mol Nutr Food Res 57, 698-708

35. Park, J. Y., Vollset, S. E., Melse-Boonstra, A., Chajes, V., Ueland, P. M., and Slimani, N. (2013) Dietary intake and biological measurement of folate: a qualitative review of validation studies. Mol Nutr Food Res 57, 562-581

36. Roth, C., Bjorke-Monsen, A. L., Reichborn-Kjennerud, T., Nilsen, R. M., Smith, G. D., Stoltenberg, C., Suren, P., Susser, E., Ueland, P. M., Vollset, S. E., and Magnus, P. (2013) Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy. Mol Nutr Food Res 57, 653-660

37. Bjorke-Monsen, A. L., Roth, C., Magnus, P., Midttun, O., Nilsen, R. M., Reichborn-Kjennerud, T., Stoltenberg, C., Susser, E., Vollset, S. E., and Ueland, P. M. (2013) Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. Mol Nutr Food Res 57, 645-652

38. Nurk, E., Refsum, H., Bjelland, I., Drevon, C. A., Tell, G. S., Ueland, P. M., Vollset, S. E., Engedal, K., Nygaard, H. A., and Smith, D. A. (2013) Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr 109, 511-519

2012

1. Borgeraas, H., Strand, E., Ringdal Pedersen, E., Dierkes, J., Ueland, P. M., Seifert, R., Wilberg, E. R., Bohov, P., Berge, R. K., Nilsen, D. W., and Nygard, O. (2012) Omega-3 Status and the Relationship between Plasma Asymmetric Dimethylarginine and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease. Cardiology research and practice 2012, 201742

2. Midttun, O., Kvalheim, G., and Ueland, P. M. (2013) High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS. Anal Bioanal Chem 405, 2009-2017

3. Eussen, S. J., Nilsen, R. M., Midttun, O., Hustad, S., N, I. J., Meyer, K., Fredriksen, A., Ulvik, A., Ueland, P. M., Brennan, P., Johansson, M., Bueno-de-Mesquita, B., Vineis, P., Chuang, S. C., Boutron-Ruault, M. C., Dossus, L., Perquier, F., Overvad, K., Teucher, B., Grote, V. A., Trichopoulou, A., Adarakis, G., Plada, M., Sieri, S., Tumino, R., de Magistris, M. S., Ros, M. M., Peeters, P. H., Redondo, M. L., Zamora-Ros, R., Chirlaque, M. D., Ardanaz, E., Sonestedt, E., Ericson, U., Schneede, J., van Guelpen, B., Wark, P. A., Gallo, V., Norat, T., Riboli, E., and Vollset, S. E. (2013) North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Br J Nutr 110, 363-374

4. Vogiatzoglou, A., Smith, A. D., Nurk, E., Drevon, C. A., Ueland, P. M., Vollset, S. E., Nygaard, H. A., Engedal, K., Tell, G. S., and Refsum, H. (2013) Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E epsilon4: the Hordaland Homocysteine Study. Psychosomatic medicine 75, 20-29

5. Torsvik, I. K., Markestad, T., Ueland, P. M., Nilsen, R. M., Midttun, O., and Bjorke Monsen, A. L. (2013) Evaluating iron status and the risk of anemia in young infants using erythrocyte parameters. Pediatric research 73, 214-220

6. Jung, A. Y., Botma, A., Lute, C., Blom, H. J., Ueland, P. M., Kvalheim, G., Midttun, O., Nagengast, F., Steegenga, W., and Kampman, E. (2013) Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas. Mol Nutr Food Res 57, 698-708

7. Park, J. Y., Vollset, S. E., Melse-Boonstra, A., Chajes, V., Ueland, P. M., and Slimani, N. (2013) Dietary intake and biological measurement of folate: a qualitative review of validation studies. Mol Nutr Food Res 57, 562-581

8. Roth, C., Bjorke-Monsen, A. L., Reichborn-Kjennerud, T., Nilsen, R. M., Smith, G. D., Stoltenberg, C., Suren, P., Susser, E., Ueland, P. M., Vollset, S. E., and Magnus, P. (2013) Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy. Mol Nutr Food Res 57, 653-660

9. Bjorke-Monsen, A. L., Roth, C., Magnus, P., Midttun, O., Nilsen, R. M., Reichborn-Kjennerud, T., Stoltenberg, C., Susser, E., Vollset, S. E., and Ueland, P. M. (2013) Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. Mol Nutr Food Res 57, 645-652

10. Igland, J., Vollset, S. E., Nygard, O. K., Gjessing, H. K., Ueland, P. M., and Tell, G. S. (2012) Relative importance of risk factors for coronary heart disease--the Hordaland Homocysteine study. Scandinavian cardiovascular journal : SCJ 46, 316-323

11. Gloyn, A. L., Faber, J. H., Malmodin, D., Thanabalasingham, G., Lam, F., Ueland, P. M., McCarthy, M. I., Owen, K. R., and Baunsgaard, D. (2012) Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers. PLoS One 7, e40962

12. Galluzzi, L., Vitale, I., Senovilla, L., Olaussen, K. A., Pinna, G., Eisenberg, T., Goubar, A., Martins, I., Michels, J., Kratassiouk, G., Carmona-Gutierrez, D., Scoazec, M., Vacchelli, E., Schlemmer, F., Kepp, O., Shen, S., Tailler, M., Niso-Santano, M., Morselli, E., Criollo, A., Adjemian, S., Jemaa, M., Chaba, K., Pailleret, C., Michaud, M., Pietrocola, F., Tajeddine, N., de La Motte Rouge, T., Araujo, N., Morozova, N., Robert, T., Ripoche, H., Commo, F., Besse, B., Validire, P., Fouret, P., Robin, A., Dorvault, N., Girard, P., Gouy, S., Pautier, P., Jagemann, N., Nickel, A. C., Marsili, S., Paccard, C., Servant, N., Hupe, P., Behrens, C., Behnam-Motlagh, P., Kohno, K., Cremer, I., Damotte, D., Alifano, M., Midttun, O., Ueland, P. M., Lazar, V., Dessen, P., Zischka, H., Chatelut, E., Castedo, M., Madeo, F., Barillot, E., Thomale, J., Wistuba, II, Sautes-Fridman, C., Zitvogel, L., Soria, J. C., Harel-Bellan, A., and Kroemer, G. (2012) Prognostic impact of vitamin B6 metabolism in lung cancer. Cell reports 2, 257-269

13. Joubert, B. R., Haberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, O., Cupul-Uicab, L. A., Ueland, P. M., Wu, M. C., Nystad, W., Bell, D. A., Peddada, S. D., and London, S. J. (2012) 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environmental health perspectives 120, 1425-1431

14. Christensen, M. H., Pedersen, E. K., Nordbo, Y., Varhaug, J. E., Midttun, O., Ueland, P. M., Nygard, O. K., Mellgren, G., and Lien, E. A. (2012) Vitamin B6 status and interferon-gamma-mediated immune activation in primary hyperparathyroidism. Journal of internal medicine 272, 583-591

15. Nurk, E., Refsum, H., Bjelland, I., Drevon, C. A., Tell, G. S., Ueland, P. M., Vollset, S. E., Engedal, K., Nygaard, H. A., and Smith, D. A. (2013) Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. Br J Nutr 109, 511-519

16. Ueland, P. M., and Loscalzo, J. (2012) Homocysteine and cardiovascular risk: the perils of reductionism in a complex system. Clinical chemistry 58, 1623-1625

17. Nilsen, R. M., Bjorke-Monsen, A. L., Midttun, O., Nygard, O., Pedersen, E. R., Ulvik, A., Magnus, P., Gjessing, H. K., Vollset, S. E., and Ueland, P. M. (2012) Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. Obstetrics and gynecology 119, 1243-1250

18. Bjorke-Monsen, A. L., Torsvik, I. K., Ueland, P. M., Saetran, H. A., and Sandberg, S. (2012) Increased yet iron-restricted erythropoiesis in postpartum mothers. Annals of hematology 91, 1435-1441

19. Ulvik, A., Midttun, O., Pedersen, E. R., Nygard, O., and Ueland, P. M. (2012) Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. Am J Clin Nutr 95, 1072-1078

20. Kvalvik, L. G., Nilsen, R. M., Skjaerven, R., Vollset, S. E., Midttun, O., Ueland, P. M., and Haug, K. (2012) Self-reported smoking status and plasma cotinine concentrations among pregnant women in the Norwegian Mother and Child Cohort Study. Pediatric research 72, 101-107

21. Hustad, S., Eussen, S., Midttun, O., Ulvik, A., van de Kant, P. M., Morkrid, L., Gislefoss, R., and Ueland, P. M. (2012) Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism. Clinical chemistry 58, 402-410

22. Wallace, J. M., McCormack, J. M., McNulty, H., Walsh, P. M., Robson, P. J., Bonham, M. P., Duffy, M. E., Ward, M., Molloy, A. M., Scott, J. M., Ueland, P. M., and Strain, J. J. (2012) Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. Br J Nutr 108, 1264-1271

23. Leenders, M., Chuang, S. C., Dahm, C. C., Overvad, K., Ueland, P. M., Midttun, O., Vollset, S. E., Tjonneland, A., Halkjaer, J., Jenab, M., Clavel-Chapelon, F., Boutron-Ruault, M. C., Kaaks, R., Canzian, F., Boeing, H., Weikert, C., Trichopoulou, A., Bamia, C., Naska, A., Palli, D., Pala, V., Mattiello, A., Tumino, R., Sacerdote, C., van Duijnhoven, F. J., Peeters, P. H., van Gils, C. H., Lund, E., Rodriguez, L., Duell, E. J., Perez, M. J., Molina-Montes, E., Castano, J. M., Barricarte, A., Larranaga, N., Johansen, D., Lindkvist, B., Sund, M., Ye, W., Khaw, K. T., Wareham, N. J., Michaud, D. S., Riboli, E., Xun, W. W., Allen, N. E., Crowe, F. L., Bueno-de-Mesquita, H. B., and Vineis, P. (2012) Plasma cotinine levels and pancreatic cancer in the EPIC cohort study. Int J Cancer 131, 997-1002