Child Health Research Project

 

Main funding is EU-INCO-DC, project 003740 Community- and health facility-based intervention with zinc as adjuvant therapy for pneumonia to enhance child health and nutrition.


 

The two components on zinc and pneumonia in Nepal are:


1. In a community based clinical trial in 2700 Nepalese children we assess the efficacy of giving 10 or 20 mg elemental zinc during pneumonia. We also measure the effect of this short-term zinc administration for 6 months after zinc has been given. The main outcome during the 6-month follow-up is number episodes of common infections. Furthermore, the thymus sizes are measured and we collect nasopharyngeal aspirates of the enrolled children to detect viral pathogens using PCR in a laboratory that we have established in Nepal. Scheduled last day of enrollment Feb 28, 2007. We are using the Hexaplex plus system from prodesse (www. prodesse.com). Detects Influenza A and B Viruses, Parainfluenza 1,2,3, Respiratory Syncytial Virus and Human Metapneumovirus

2. In a hospital based clinical trial in 900 Nepalese children, 2-35 months of age we assess the effect of giving 10 or 20 mg elemental zinc during severe pneumonia. We will compare the time until recovery between children that receive zinc and children that are given placebo. The children will be followed until discharge from the hospital. Scheduled last day of enrollment Dec 31, 2007.

 

Both trials are  registered in: 
http://www.clinicaltrials.gov/ct/show/NCT00252304
http://www.clinicaltrials.gov/ct/show/NCT00148733

 

Main "Add on" studies

1. Case-control study on the viral etiology of outpatient-treated childhood pneumonia. (Sample size approximately 2000)

2. Case-control study on indoor air pollution and the risk of childhood pneumonia.

 

OBJECTIVES AND GOALS

Collaborators

 

NORWAY

Dr. Strand Tor A, Email: tor.strand@cih.uib.no,  Tel: + 47 55974980, Fax: + 47 55974979

Dr., Prof. Bhandari Nita Email: community.research@cih.uib.no  Tel: + 91 11 26014136, Fax: + 91 11 26016449

Dr. Prof. Sommerfelt Halvor, Email: halvor.sommerfelt@cih.uib.no, Tel: + 47 55974987, Fax: + 47 55974979

Dr. Mathisen Maria, Email: maria.mathisen@cih.uib.no, Tel: + 47 55974987, Fax: + 47 55974979

University of Bergen
Faculty of Medicine
Centre for International Health   
Armeuer Hansen Building    

5021 Bergen, Norway 

NEPAL

Dr. Prof. Adhikari Ramesh K, E-mail: ramesh@healthnet.org.np, Tel: +977 14 412 202, Fax: +977 14 411 886

Dr. Prof. Shrestha Prakash S, E-mail: psshrestha00@hotmail.com, Tel: +977 14 412 202, Fax: +977 14 411 886

Dr. Chandyo Ram K E-mail: ram.chandyo@cih.uib.no, Tel: +977 14 412 202, Fax: +977 14 411 886

Dr. Basnet Sudha E-mail: sudhab@healthnet.org.np, Tel: +977 14 412 202, Fax: +977 14 411 886

Tribhuvan University

Institute of Medicine   

Department of Child Health   

Maharajgung,

Kathmandu,

Nepal    

DENMARK

Dr. Branth Palle V, E-mail: pvb@ssi.dk, Tel: +45 32 68 32 69, Fax: +45 32 68 31 65

Statens Serum Institut

Department of Epidemilogy Research  

Artillerivej 5,
2300 Copenhagen, Denmark

INDIA 1

Dr. Prof Bhan Maharaj K, E-mail: community.research@cih.uib.no, Tel: +91 11 265 88 822, Fax: +91 11 265 88 663

Dr. Bhatnagar Shinjini, E-mail: shinjini_bhatnagar@rediffmail.com, Tel: 91-11-26593290, Fax: 91-11-26588663/26588641

All India Institute of Medical Sciences

ICMR Advanced Centre for Diarrheal Disease Research

Department of Pediatrics

Ansari Nagar, New Delhi-110029, India

 

INDIA 2

Mahalanabis Dilip, E-mail: dmahalanabis@vsnl.com, Tel: +91 33 2337 8850, Fax: +91 33 2337 6290

Bhandari Nita, E-mail: community.research@cih.uib.no, Tel: + 91 11 26014136. Fax: + 91 11 26016449

Society for Applied Studies

108 Manicktala Main Road

Kolkata 700054

India

FRANCE

Simondon Kirsten B, E-mail: kirsten.simondon@mpl.ird.fr, Tel: +33 4 67 41 63 32, Fax: +33 4 67 41 63 30

Institut de Recherche pour le Deloppement

Epidemiologie et Prevention

911 Avenue Agropolis BP 64501

34394 Montpellier Cedex 5

France