2-Aminoadipic acid


Synonyms: 2-Aminohexanedioic acid, alpha-aminoadipic acid.
Method(s): GC-MS/MS (1).

What is measured on the same platform, click here.
Platform B: MMA, tHcy, tCys, Met, Ser, Gly, Cysta, Sarc, His, Trp, Kyn, (KTR), HK, KA, XA, AA, HAA, NA, PA, Figlu, Orn, Asp, Glu, Lys, Ala, Phe, Ile, Leu, Pro, Val, Asn, Gln, Thr, Tyr, aKG, 3HIB, aHB, bHB, AcAc, CML, CEL, 2AAA

What is 2-aminoadipic acid?

Aminoadipic acid (2-aminoadipate; 2-AAA) is formed through lysine metabolism or degradation of tissues or plasma proteins. Such degradation has been associated with ageing, renal failure and diabetes, and may be part of a carbonyl stress pathway in diabetes. 2-AAA has neuroexcitatory properties, possible by inhibiting the production of kynurenic acid. Most important, plasma 2-AAA is a strong predictor of incident diabetes, independent of other risk factors (2). The association with diabetes risk has been explained by stimulation of insulin secretion by 2-AAA, as observed in experimental studies.

Performance of the assay

Lower limit of detection (LOD): na.
Within-day CV: 5 %; between-day CV: na.

Indication(s)

Assessment of risk of diabetes type 2.

Specimen, collection and processing

Patient/subject: No special precaution.
Matrix: Serum or EDTA plasma.
Volume: Minimum volume is 50 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: Stable.

Transportation; for general instruction on transportation, click here.

Frozen, on dry ice.

Reported values, interpretation

Reported values: 0.3-2 µmol/L
Intraclass correlation coefficient (ICC): na.

Literature

1. Midttun, Ø., McCann, A., Aarseth, O., Krokeide, M., Kvalheim, G., Meyer, K., and Ueland, P.M. (2016). Combined measurement of 6 fat-soluble vitamins and 26 water-soluble functional vitamin markers and amino acids in 50 μL of serum or plasma by high-throughput mass spectrometry. Anal Chem 88, 10427-436.
2. Wang, T.J., Ngo, D., Psychogios, N., Dejam, A., Larson, M.G., Vasan, R.S., Ghorbani, A., O'Sullivan, J., Cheng, S., et al. (2013). 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest 123, 4309-317.