β-Amino-isobutyrate


Synonyms: Beta-aminoisobutyric acid, BAIBA, 3-aminoisobutyrate, 3-amino-2-methylpropanoate
Method(s): GC-MS/MS (1).

What is measured on the same platform, click here.
Platform B: MMA, tHcy, tCys, Met, Ser, Gly, Cysta, Sarc, His, Trp, Kyn, (KTR), HK, KA, XA, AA, HAA, NA, PA, Figlu, Orn, Asp, Glu, Lys, Ala, Phe, Ile, Leu, Pro, Val, Asn, Gln, Thr, Tyr, aKG, 3HIB, aHB, bHB, AcAc, CML, CEL, 2AAA, BAIBA, BAIBA

What is β-aminoisobutyrate?

Beta-aminoisobutyric acid (BAIBA) is a catabolite of valine and thymine. BAIBA is increased after endurance exercise, a response mediated by PGC-1α, and induces increased beta-oxidation and browning of white adipose tissue in mice. In humans, BAIBA in plasma is increased by regular exercise, and inversely associated with cardiometabolic risk factors, such as fasting glucose, insulin, HOMAR-IR, total cholesterol and triglycerides (2).

Performance of the assay

Lower limit of detection (LOD): na.
Within-day CV: 5 %; between-day CV: na.

Indication(s)

Assessment of cardiovascular risk and risk of diabetes.

Specimen, collection and processing

Patient/subject: No special precaution.
Matrix: Serum or EDTA plasma.
Volume: Minimum volume is 50 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: Probably stable.

Transportation; for general instruction on transportation, click here.

Frozen, on dry ice.

Reported values, interpretation

Reported values: 0.3-2.0 µmol/L
Intraclass correlation coefficient (ICC): na.

Literature

1. Midttun, Ø., McCann, A., Aarseth, O., Krokeide, M., Kvalheim, G., Meyer, K., and Ueland, P.M. (2016). Combined measurement of 6 fat-soluble vitamins and 26 water-soluble functional vitamin markers and amino acids in 50 μL of serum or plasma by high-throughput mass spectrometry. Anal Chem 88, 10427-436.
2. Tanianskii, D. A., Jarzebska, N., Birkenfeld, A. L., O’Sullivan, J. F., and Rodionov, R. N. (2019). Beta-aminoisobutyric acid as a novel regulator of carbohydrate and lipid metabolism. Nutrients, 11(3), E524.