Organic synthesis and transition metal catalysis is a focused area of the research group, that includs development of new and improved cataytic reactions, and new synthetic pathways in which transition metal catalysis are involved as an important part of a total synthesis.
We are particularly interested in the synthesis of N-heterocyclic compounds, such as benzo[c]cinnolines, carbazoles, phenothiazines, and imidazoles with relevance in medicinal chemistry. The imidazole framework is of particular interest as this motif can be used as precursor for NHC ligands used in organometallics for various catalysts, for example for olefin metathesis, Suzuki cross-coupling, and oxidation catalysts.
Free organic radicals for synthetic applications, development of green chemistry methods for the oxidation reactions in organic synthesis has been an long standing research activity in the research group. This research activity involves also studies of antioxidants and development of new total syntheses of such compounds. but this area of reserach have been minor focused in the group during recent years.
Development and investigation of continuous flow organic synthesis reactor systems and combined reaction and work-up platforms are important and long standing reserach activity in the group. We have successfully developed a novel approach for flow chemistry that is realized in a milli-reactor platform that we have named multi-jet oscillation disk (MJOD) milli-reactor system.
KJEM131 Organic Synthesis and Analysis (past)
KJEM232 Experimental Organic Synthesis
KJEM233 Organic mass spectrometry (past)
KJEM335 Physical Organic Chemistry (past)
FARM236 Medicinal Chemistry
Organometallic reactions in organic synthesis
N-heterocyclic carbenes in synthesis
Experimental design and modelling in organic synthesis
Free radical reactions in synthetic organic chemistry
Instrumental methods in organic synthesis
Experimental organic synthesis and spectroscopy (project)
- Hans-René Bjørsvik,* Bjørn Tore Gjertsen, Vijayaragavan Elumalai. Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest. ChemMedChem 2020, 15, 862–870.
- Eirin Alme, Karl Wilhelm Törnroos, Bjørn Tore Gjertsen, and Hans-René Bjørsvik.* Synthesis of N-Aryl- and N-alkyl-Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia. ChemMedChem 2020, 15, 1509-1514.
- Davide Cirillo, Francesco Angelucci, Hans-René Bjørsvik.* Functionalization of the imidazole backbone by means of a tailored and optimized oxidative Heck cross‐coupling. Advanced Catalysis and Synthesis 2020, 362, 5079-5092.