Organic synthesis and transition metal catalysis is a focused area of the research group, that includs development of new and improved cataytic reactions, and new synthetic pathways in which transition metal catalysis are involved as an important part of a total synthesis.
We are particularly interested in the synthesis of N-heterocyclic compounds, such as benzo[c]cinnolines, carbazoles, phenothiazines, and imidazoles with relevance in medicinal chemistry. The imidazole framework is of particular interest as this motif can be used as precursor for NHC ligands used in organometallics for various catalysts, for example for olefin metathesis, Suzuki cross-coupling, and oxidation catalysts.
Free organic radicals for synthetic applications, development of green chemistry methods for the oxidation reactions in organic synthesis has been an long standing research activity in the research group. This research activity involves also studies of antioxidants and development of new total syntheses of such compounds. but this area of reserach have been minor focused in the group during recent years.
Development and investigation of continuous flow organic synthesis reactor systems and combined reaction and work-up platforms are important and long standing reserach activity in the group. We have successfully developed a novel approach for flow chemistry that is realized in a milli-reactor platform that we have named multi-jet oscillation disk (MJOD) milli-reactor system.
|PET Imaging in Drug Design and Development (PET3D) project - A European Marie Sklodowska-Curie Actions (MSCA) Innovative Training Network (ITN)
Contemporary drug development is rather inefficient and difficult to sustain. To keep drug development affordable, it should become more efficient and rationalized. Molecular imaging can play a pivotal role in changing the landscape of drug design and development and improving the health care system. Positron Emission Tomography (PET) imaging, in particular, is the technology that has the potential to lead this fundamental innovation by providing at a much earlier stage reliable answers to key questions emerging during the care cycle: what and where is the disease? Is the disease accurately targeted by the therapy? Is the treatment effective? By answering the questions above, PET imaging has the capacity to render much more effectively the transition from pre-clinical to clinical phase, and to strongly facilitate the development of better drugs at an earlier stage and in a much more sustainable manner. However, new radiolabelled compounds, so-called tracers, are required to be able to use PET successfully.
The Bergen section of the PET3D consortium shall design, develop and optimize new synthetic methods necessary for the synthesis of new tracers targeting hypoxic tumour tissue, NTR-bioreductive probes, and/or targeted drug delivery. To achieve that we will synthesize and characterize highly functionalized radiolabeled (18F or 11C) 2- and 4-nitroimidazoles and/or other biologically relevant compounds. The novel scaffolds will be investigated as radiotracers at the pre-clinical PET/CT-scanner at Haukeland University Hospital.
KJEM131 Organic Synthesis and Analysis (past)
KJEM232 Experimental Organic Synthesis
KJEM233 Organic mass spectrometry (past)
KJEM335 Physical Organic Chemistry (past)
FARM236 Medicinal Chemistry
Organometallic reactions in organic synthesis
Experimental organic synthesis and spectroscopy (project)
N-heterocyclic carbenes in synthesis
Free radical reactions in synthetic organic chemistry
Instrumental methods in organic synthesis
Experimental design and modelling in organic synthesis
- Vijayaragavan Elumalai, Alexander H. Sandtorv, and Hans-René Bjørsvik.* A Highly Efficient Pd(PPh3)4-Catalyzed Suzuki Cross-Coupling Method for the Preparation of 2-Nitrobiphenyls from 1-Chloro-2-Nitrobenzenes and Phenylboronic acids. European Journal of Organic Chemistry 2016, 1344-1354.
- Marta Ferreri, Audun Drageset, Cristian Gambarotti, and Hans-René Bjørsvik.* Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation. Reaction Chemistry & Engineering 2016, 1, 379-386.
- Audun Drageset and Hans-René Bjørsvik.* Continuous flow synthesis cocatenated with continious flow liquid-liquid extraction for work-up and purification: selective mono- and di-iodination of the imidazole backbone. Reaction Chemistry & Engineering 2016, 1, 436-444.
- Hans-René Bjørsvik* and Vijayaragavan Elumalai. Synthesis of the Carbazole Scaffold Direcly form 2-amino-biphenyl by means of tandem C-H activation and C-N bond formation. European Journal of Organic Chemistry 2016, 5474-5479.
- Vijayaragavan Elumalai and Hans-René Bjørsvik.* A Concise Synthesis to Benzo[c]cinnolines via 2,2´-Dinitro-1,1´-Biphenyls Attained from a Novel Tailored Suzuki Cross-Coupling. ChemistrySelect 2017, 2, 9387-9390
- Vijayaragavan Elumalai, Cristian Gambarotti, and Hans-René Bjørsvik.* Carbazomycin G: Method Development and Total Synthesis. European Journal of Organic Chemistry 2018, 1984–1992.
- Frida Johanne Lundevall, Vijayaragavan Elumalai, Audun Drageset, Christian Totland, Hans-René Bjørsvik.* A Co2B mediated NaBH4 reduction protocol applicable for a selection of functional groups in organic synthesis. European Journal of Organic Chemistry 2018, 3416-3425.
- Audun Drageset, Hans-René Bjørsvik.* Synthesis of amides from alcohols and amines thru a domino oxidative amidation and telescoped transamidation process. European Journal of Organic Chemistry 2018, 4436-4445.
- Audun Drageset, Vijayaragavan Elumalai, Hans-René Bjørsvik.* Synthesis of Boscalid via a Three-step Telescoped Continuous Flow Process Implemented on a MJOD Reactor Platform. Reaction Chemistry & Engineering 2018, 3, 550-558
- Audun Drageset, Nils Åge Frøystein, Karl Wilhelm Törnroos, Hans-René Bjørsvik.* A two-step telescoped continious flow switchable process leading to nitriles, diaziridinee or hydrazine derivatives. Reaction Chemistry & Engineering 2019, 4, 41-51.
- Cristian Gambarotti, Hans-René Bjørsvik.* Amino-TEMPO grafted on magnetic multi walled nanotubes: An efficient and recyclable heterogenious oxidation catalyst. European Journal of Organic Chemistry 2019, 1405-1412.